I like the flat colour and confident line used in many comic strips, for example in the Adventures of Tintin, but my wiry pen drawing is better suited to watercolour.
A flat flesh colour wouldn’t give a true impression of the back of my hand which has yellowish and reddish patches plus a variety of browns and warm greys in the shadows. It looks lived in. Using pen and watercolour runs the risk of overloading the comic strip with visual information but I think it’s worth trying to make it work. My section of the story is set in a wildlife sanctuary so watercolour going to work well for the colours and texture of the natural world. In his autobiography, Waterton describes himself as looking as if he has spent his life out of doors in all weathers, so he needs to look like a part of the natural world too.